THE SCIENCE BEHIND DEEP STRUCTURAL SUPPORT

Skincare supplement, read the research.

The science behind our skincare supplement is documented in over 30 peer-reviewed clinical trials of collagen peptides and hyaluronic acid, plus published research on vitamin C's role as a collagen-synthesis cofactor, all in PubMed-indexed medical journals.

Reviewed:

30+CLINICAL TRIALS

  • 26 Collagen peptide RCTs
  • 7 Hyaluronic acid RCTs

THE THESIS

Across our two core bioactive ingredients, independent researchers have published 33 randomized, placebo-controlled clinical trials measuring skin hydration, elasticity, wrinkle depth, and dermal density. Vitamin C is included as an essential cofactor for collagen synthesis, validated in clinical trials studying oral collagen plus vitamin C formulations.

01INGREDIENT STRUCTURE-FORMING PROTEIN

Hydrolyzed Collagen Peptides.

The most abundant structural protein in your skin. Production declines as we age.

Hydrolyzed collagen peptides are absorbed into the bloodstream and reach the skin, where research suggests they support collagen synthesis. Three independent meta-analyses confirm oral collagen improves skin hydration and elasticity versus placebo.

DSS DOSE 7,800 mgwithin the 2,500 to 10,000 mg/day range used in the cited clinical trials.

POOLED META-ANALYSES, RCT CONCLUSIONSDIFFERENT TEAMS. DIFFERENT COUNTRIES. DIFFERENT POOLS.

  • 26 RCTs

    1,721 PARTICIPANTS

    Statistically significant improvements in skin hydration and elasticity versus placebo (p < 0.00001 for both).

    Pu et al. Nutrients, 2023.

  • 19 RCTs

    1,125 PARTICIPANTS

    Significant improvement in wrinkles versus placebo across pooled trials.

    de Miranda et al. International Journal of Dermatology, 2021.

  • 14 RCTs

    967 PARTICIPANTS

    Oral collagen supplementation shown to reduce visible signs of aging in skin.

    Dewi et al. Cureus, 2023.

HIGHLIGHTED TRIALS3 OF 26
  • Bolke et al. 2019

    Randomized, placebo-controlled, blind study. Oral collagen shown to improve hydration, elasticity, roughness, and dermal density.

    Nutrients, 2019.

  • Asserin et al. 2015

    Oral collagen peptides improved skin moisture and the dermal collagen network in clinical measurement and in-vivo skin models.

    Journal of Cosmetic Dermatology, 2015.

  • BCP Trial 2025

    77 women received 5,000 mg/day for 12 weeks. High-resolution ultrasound showed significant improvements in hydration, elasticity, and dermal thickness, with benefits persisting during a 4-week washout after supplementation stopped.

    PMC12661388.

02INGREDIENT SODIUM HYALURONATE

Hyaluronic Acid.

Your skin holds roughly half of all the hyaluronic acid in your body. Concentration declines significantly with age.

Once it's there, it keeps skin plump, hydrated, and resilient. Oral HA supplementation has been shown to replenish skin hydration and reduce wrinkle depth from the inside out. Published trials tested doses from 60 to 200 mg per day; DSS provides 50 mg, at or just below the lowest studied arm.

DSS DOSE 50 mg sodium hyaluronateat or just below the lowest studied dose; trials tested 60 to 200 mg per day.

POOLED ANALYSIS7 RANDOMIZED, CONTROLLED TRIALS

  • 7 RCTs

    Statistically significant improvements in skin hydration, elasticity, and wrinkle depth versus placebo.

    Journal of Drugs in Dermatology, 2025.

HIGHLIGHTED TRIALS3 OF 7
  • Scientific Reports 2025

    A 150-person clinical trial showed oral hyaluronic acid improves hydration and wrinkle depth. Studied doses (60 and 120 mg) sit above the 50 mg DSS dose, so this finding is framed as an ingredient-class effect.

    Scientific Reports, 2025.

  • Hsu et al. 2021

    40 adults, 120 mg/day, 12 weeks, double-blind. Significant improvements in wrinkles, hydration, water retention, and elasticity versus placebo, measurable by week 8.

    Nutrients, 2021.

  • Gao et al. 2023

    120 women across younger and older age groups. Oral hyaluronic acid showed improvements in skin condition starting at 2 weeks, with measurable epidermal thickness gains by 12 weeks across both age groups.

    Skin Research and Technology, 2023.

03COFACTOR REQUIRED BY THE COLLAGEN-BUILDING ENZYMES

Vitamin C.

The essential cofactor for the enzymes that fold, stabilize, and assemble collagen. Humans can't produce it internally.

Vitamin C is required by prolyl and lysyl hydroxylases, the enzymes that cross-link collagen fibers into their triple-helix structure. It also activates collagen gene transcription and inhibits MMP-1, the enzyme that breaks existing collagen down. Without it, fibroblasts are unable to fully assemble the collagen they produce.

DSS DOSE 100 mgper serving. See dose context band below for how this relates to the cited trial doses.

STUDIED IN CLINICAL TRIALS COMBINING COLLAGEN PEPTIDES AND VITAMIN C4 TRIALS. DOUBLE-BLIND. PLACEBO-CONTROLLED.

  • 44.6%

    decrease in collagen fragmentation

    In a 12-week clinical trial of hydrolyzed collagen plus vitamin C, participants saw a 44.6% decrease in collagen fragmentation versus placebo. Reilly et al., Dermatology Research and Practice, 2024 (PMID 39021368). Daily use.

  • 13.8%

    increase in skin hydration

    In a 12-week clinical trial of hydrolyzed collagen plus vitamin C, participants saw a 13.8% increase in skin hydration versus placebo. Reilly et al., Dermatology Research and Practice, 2024. Daily use.

  • 22.7%

    increase in skin elasticity

    In a 12-week clinical trial of hydrolyzed collagen plus vitamin C, participants saw a 22.7% increase in skin elasticity versus placebo. Reilly et al., Dermatology Research and Practice, 2024. Daily use.

  • 19.6%

    reduction in wrinkle depth

    In a 12-week clinical trial of hydrolyzed collagen plus vitamin C, participants saw a 19.6% reduction in wrinkle depth versus placebo. Reilly et al., Dermatology Research and Practice, 2024. Daily use.

The authors describe vitamin C as a key factor driving efficacy of these supplements.

Reilly et al., Dermatology Research and Practice, 2024.

TRIAL 02 BETWEEN AGES 40 AND 65 12 WEEKS

In a separate 12-week clinical trial, collagen + 80 mg vitamin C improved dermis density, skin texture, and wrinkle severity versus placebo. The trial also tested adding hyaluronic acid and did not find HA to add measurable benefit beyond collagen + vitamin C alone.

Žmitek et al., Nutrients, 2024 (PMC11206740).

WHY 100 MG?Humans can't produce vitamin C internally. 100 mg per serving sits in the same range as the doses tested in the cited clinical trials (Reilly 2024: 60 mg; Žmitek 2024: 80 mg) and within the studied effective range of 80 to 200 mg.

METHODOLOGY

How we count to 30+.

26 Collagen peptide RCTsPu et al. 2023 meta-analysis.
7 Oral hyaluronic acid RCTsJournal of Drugs in Dermatology, 2025 meta-analysis.
33 trials reviewed across the two ingredient classes.

Trials counted in this review are peer-reviewed, randomized, placebo-controlled, oral supplementation studies in healthy adult populations. Inclusion criteria pulled directly from the two meta-analyses cited in the equation on the left.

References

At the end of each reference entry, the existing identifiers, like this, click through to read the source open on PubMed or the journal of record.

  1. [1]

    Pu S, et al. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis. Nutrients. 2023.

    View source
  2. [2]

    de Miranda RB, et al. Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. International Journal of Dermatology. 2021.

    View source
  3. [3]

    Dewi NMAR, et al. The efficacy and safety of oral collagen supplementation for skin anti-aging: a meta-analysis. Cureus. 2023.

    View source
  4. [4]

    Bolke L, et al. A collagen supplement improves skin hydration, elasticity, roughness, and density: results of a randomized, placebo-controlled, blind study. Nutrients. 2019.

    View source
  5. [5]

    Asserin J, et al. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network. Journal of Cosmetic Dermatology. 2015.
  6. [6]

    Bioactive collagen peptide trial. Skin benefits persisting after supplementation. 2025.

    View source
  7. [7]

    Oral hyaluronic acid supplementation: a meta-analysis. Journal of Drugs in Dermatology. 2025.

    View source
  8. [8]

    Oral hyaluronic acid clinical trial. Scientific Reports. 2025.

    View source
  9. [9]

    Hsu TF, et al. Oral hyaluronan supplementation for skin hydration and wrinkles. Nutrients. 2021.

    View source
  10. [10]

    Gao YR, et al. Oral hyaluronic acid improves skin condition. Skin Research and Technology. 2023.

    View source
  11. [11]

    Reilly DM, et al. Hydrolyzed collagen peptides plus vitamin C: a clinical trial of skin parameters. Dermatology Research and Practice. 2024.

    View source
  12. [12]

    Žmitek K, et al. The effect of hydrolyzed collagen with vitamin C and other parameters. Nutrients. 2024.

    View source
  13. [13]

    Al-Niaimi F, Chiang NYZ. Topical vitamin C and the skin: mechanisms of action and clinical applications. Journal of Clinical and Aesthetic Dermatology. 2017.

    View source
  14. [14]

    Meyer LJM, Stern R. Age-dependent changes of hyaluronan in human skin. Journal of Investigative Dermatology. 1994.
  15. [15]

    Kawada C, et al. Ingested hyaluronan moisturizes dry skin. 2015.

These statements have not been evaluated by the Food and Drug Administration.

This product is not intended to diagnose, treat, cure, or prevent any disease.

Individual results may vary. Results cited in clinical trials reflect daily use as tested in those trials.