The Science Behind Deep Structural Support

We don't make claims.
We cite them.

Every active ingredient in Deep Structural Support is backed by peer-reviewed clinical research published in PubMed-indexed medical journals. Here's the evidence — study by study.

30+

Key ingredients studied in 30+ randomized, placebo-controlled trials

Across our two core bioactive ingredients — hydrolyzed collagen peptides and oral hyaluronic acid — independent researchers have published over 33 randomized, placebo-controlled clinical trials measuring skin hydration, elasticity, wrinkle depth, and dermal density. Vitamin C is included as an essential cofactor for collagen synthesis, validated in clinical trials studying oral collagen + vitamin C formulations.

26+
Collagen Peptide Trials
Skin hydration, elasticity & wrinkles
7+
Oral Hyaluronic Acid Trials
Skin hydration & wrinkle depth
33+
Combined Skin-Specific Trials
All randomized & placebo-controlled

Hydrolyzed Collagen Peptides

7,800 mg per serving

Collagen peptides are the most studied oral ingredient for skin aging. When you take hydrolyzed collagen, it's absorbed as small peptides (like Pro-Hyp and Gly-Pro-Hyp) that reach the skin via the bloodstream and signal fibroblasts to produce new collagen. Multiple independent meta-analyses — pooling dozens of clinical trials and thousands of participants — confirm measurable improvements in skin hydration, elasticity, and wrinkle reduction.

Meta-Analysis
Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis
Nutrients, 2023 · Pu et al. · DOI: 10.3390/nu15092080
Pooled 26 randomized controlled trials involving 1,721 participants. Only trials using a randomized, placebo-controlled design with skin hydration or elasticity endpoints were included. Collagen supplementation significantly improved skin hydration (p < 0.00001) and elasticity (p < 0.00001) compared to placebo — with benefits consistent across collagen sources (fish, bovine, porcine) and study durations (2–12 weeks).
Meta-Analysis
Effects of Hydrolyzed Collagen Supplementation on Skin Aging: A Systematic Review and Meta-Analysis
Int J Dermatol, 2021 · de Miranda et al. · PMID: 33742704
Analyzed 19 randomized, double-blind, controlled trials with 1,125 participants (96% women). Concluded that 90 days of hydrolyzed collagen supplementation is effective in reducing wrinkles and improving skin elasticity and hydration compared to placebo. Only trials measuring skin wrinkles, hydration, elasticity, or firmness were eligible for inclusion.
Meta-Analysis
Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation
Cureus, 2023 · Prakoeswa et al. · DOI: 10.7759/cureus.49340
Encompassed 14 randomized controlled trials involving 967 participants supplemented for 4 to 12 weeks. All trials measured skin aging, wrinkles, moisture, elasticity, or firmness. Confirmed that oral collagen hydrolysate is effective in reducing visible signs of skin aging and is safe for consumption.
Clinical Trial
A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density
Nutrients, 2019 · Bolke et al. · DOI: 10.3390/nu11102494
Randomized, placebo-controlled, blind study demonstrating that oral collagen peptide supplementation significantly improved all four measured skin parameters — hydration, elasticity, roughness, and dermal density — compared to placebo.
Clinical Trial
Sustained Effects of Bioactive Collagen Peptides on Skin Health
2025 · Randomized, double-blind, placebo-controlled
77 healthy women received 5,000 mg/day of collagen peptides or placebo for 12 weeks, followed by a 4-week washout period. High-resolution ultrasound showed significant improvements in skin hydration, elasticity, and dermal thickness — with benefits persisting even after supplementation ended.

Hyaluronic Acid (as Sodium Hyaluronate)

50 mg per serving

Your skin contains roughly half of all the hyaluronic acid in your body — and its concentration declines significantly with age. Oral HA supplementation has been shown in multiple randomized, placebo-controlled trials to meaningfully improve skin hydration and reduce wrinkle depth from the inside out. A 2025 meta-analysis pooled 7 clinical trials and confirmed statistically significant results.

Meta-Analysis
Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction
Journal of Drugs in Dermatology, 2025 · PMID: 40911749
Identified 7 randomized controlled trials evaluating oral HA as a standalone supplement for skin. The pooled analysis revealed statistically significant improvements in skin hydration, elasticity, and wrinkle depth for HA supplementation compared to placebo.
Clinical Trial
Oral Sodium Hyaluronate Improves Skin Hydration, Barrier Function and Signs of Aging
Scientific Reports (Nature), 2025 · DOI: 10.1038/s41598-025-32758-5
150 healthy adults were randomized to 60 mg/day, 120 mg/day, or placebo for 12 weeks. Researchers measured facial hydration, water loss, wrinkle depth, elasticity, dermal density, and skin gloss. Both active doses showed significant improvements in hydration, barrier function, and wrinkle depth compared to placebo.
Clinical Trial
Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin
Nutrients, 2021 · Hsu et al. · DOI: 10.3390/nu13072220
Randomized, double-blind trial with 40 adults (aged 35–64) taking 120 mg daily HA for 12 weeks. Skin was significantly improved in wrinkle assessment, hydration, water retention, and elasticity compared to placebo — with measurable improvements starting at week 8.
Clinical Trial
Oral Administration of Hyaluronic Acid to Improve Skin Conditions
Skin Research and Technology, 2023 · Gao et al. · DOI: 10.1111/srt.13531
Double-blind trial with 129 women across younger and older age groups. Oral HA promoted measurable skin hydration within 2–8 weeks, improved skin tone after 4–8 weeks, and increased epidermal thickness after 12 weeks — in both age groups.

Vitamin C (as Ascorbic Acid) — Collagen Cofactor

100 mg per serving

Here's something most collagen supplements get wrong: collagen peptides stimulate your fibroblasts to produce new collagen, but your body can't actually fold, stabilize, or assemble that collagen without vitamin C. Ascorbic acid is the essential cofactor for the enzymes (prolyl and lysyl hydroxylase) that cross-link collagen fibers into their stable triple-helix structure. Without it, the collagen peptides you're paying for can't do their job. That's why we include 100 mg in every scoop.

Clinical Trial
Skin Collagen, Hydration, Elasticity and Wrinkle Improvement from Oral Hydrolysed Collagen + Vitamin C
Dermatology Research and Practice, 2024 · Reilly et al. · DOI: 10.1155/2024/8752787
Randomized, double-blind, placebo-controlled trial testing an oral collagen + vitamin C supplement. After 12 weeks, the treatment group showed a 44.6% decrease in collagen fragmentation, 13.8% increase in skin hydration, and 22.7% increase in elasticity vs placebo. The study authors specifically identified vitamin C as "a key factor driving efficacy" of collagen supplements.
Clinical Trial
Collagen + Vitamin C Supplementation: Effects on Skin Density, Texture and Wrinkles
Nutrients, 2024 · PMC11206740
87 women (aged 40–65) were randomized to receive collagen + 80 mg vitamin C, or collagen + vitamin C + hyaluronic acid, or placebo for 16 weeks. Both active groups showed significant improvements in dermis density, skin texture, and wrinkle severity compared to placebo.
Mechanism
Why Vitamin C Is Essential for Collagen
J Clinical and Aesthetic Dermatology, 2017 · Al-Niaimi & Chiang · PMID: 29104718
Vitamin C serves as a required cofactor for prolyl hydroxylase and lysyl hydroxylase — the enzymes that cross-link and stabilize collagen fibers. It also directly activates collagen synthesis gene transcription, stabilizes procollagen mRNA, and inhibits MMP-1 (the enzyme that breaks collagen down). Humans cannot produce vitamin C internally — it must come from diet or supplementation.

How we arrived at 30+

We count only skin-specific, randomized, placebo-controlled trials from published meta-analyses indexed on PubMed. Hydrolyzed collagen peptides contribute 26 RCTs (per Pu et al., Nutrients, 2023) and oral hyaluronic acid contributes 7 RCTs (per Journal of Drugs in Dermatology, 2025). Every counted trial used a randomized design with a placebo control and measured skin hydration, elasticity, wrinkle depth, or a combination of these endpoints.

Vitamin C is not counted toward the 30+ figure. It is included in the formula as a collagen synthesis cofactor with strong mechanistic evidence and direct clinical validation in oral collagen + vitamin C trials. We believe in showing our work — not inflating numbers.

See the formula behind the research

Every ingredient in Deep Structural Support was chosen because the clinical evidence demanded it.

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All cited studies are publicly available on PubMed (pubmed.ncbi.nlm.nih.gov). This page is for informational purposes only and does not constitute medical advice. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.